PMID

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Article Title

Organization

Isolation and structure of SCH 351633: a novel hepatitis C virus (HCV) NS3 protease inhibitor from the fungus Penicillium griseofulvum.

Schering-Plough Research Institute

Phenylglycine as a novel P2 scaffold in hepatitis C virus NS3 protease inhibitors.

Uppsala University

Design and synthesis of depeptidized macrocyclic inhibitors of hepatitis C NS3-4A protease using structure-based drug design.

Schering-Plough Research Institute

Control of hepatitis C: a medicinal chemistry perspective.

University of Wollongong

Antiviral compounds from traditional Chinese medicines Galla Chinese as inhibitors of HCV NS3 protease.

Peking University

Inhibition of hepatitis C virus NS3 protease activity by product-based peptides is dependent on helicase domain.

Uppsala University

NMR line-broadening and transferred NOESY as a medicinal chemistry tool for studying inhibitors of the hepatitis C virus NS3 protease domain.

Boehringer Ingelheim Pharmaceuticals

Highly potent and selective peptide-based inhibitors of the hepatitis C virus serine protease: towards smaller inhibitors.

Boehringer Ingelheim Pharmaceuticals

Peptide-based inhibitors of the hepatitis C virus serine protease.

Boehringer Ingelheim (Canada)

P2-P4 macrocyclic inhibitors of hepatitis C virus NS3-4A serine protease.

Schering-Plough Research Institute

Discovery of proline sulfonamides as potent and selective hepatitis C virus NS5b polymerase inhibitors. Evidence for a new NS5b polymerase binding site.

Wyeth Research

Design and synthesis of 3,4-dihydro-1H-[1]-benzothieno[2,3-c]pyran and 3,4-dihydro-1H-pyrano[3,4-b]benzofuran derivatives as non-nucleoside inhibitors of HCV NS5B RNA dependent RNA polymerase.

Wyeth Research

Design, synthesis, and biological activity of m-tyrosine-based 16- and 17-membered macrocyclic inhibitors of hepatitis C virus NS3 serine protease.

Schering-Plough Research Institute

Synthesis and biological activity of macrocyclic inhibitors of hepatitis C virus (HCV) NS3 protease.

Schering-Plough Research Institute

Investigation of glycine alpha-ketoamide HCV NS3 protease inhibitors: effect of carboxylic acid isosteres.

Pharmaceutical Research Institute

The design and enzyme-bound crystal structure of indoline based peptidomimetic inhibitors of hepatitis C virus NS3 protease.

Mrl Rome

P4 and P1' optimization of bicycloproline P2 bearing tetrapeptidyl alpha-ketoamides as HCV protease inhibitors.

Eli Lilly

P4 cap modified tetrapeptidyl alpha-ketoamides as potent HCV NS3 protease inhibitors.

Eli Lilly

Non-peptidic small-molecule inhibitors of the single-chain hepatitis C virus NS3 protease/NS4A cofactor complex discovered by structure-based NMR screening.

Schering-Plough Research Institute

Inhibitors of hepatitis C virus NS3.4A protease 2. Warhead SAR and optimization.

Vertex Pharmaceuticals

NMR structural characterization of peptide inhibitors bound to the Hepatitis C virus NS3 protease: design of a new P2 substituent.

Boehringer Ingelheim (Canada)

Two antiviral compounds from the plant Stylogne cauliflora as inhibitors of HCV NS3 protease.

Schering-Plough Research Institute

Novel, potent phenethylamide inhibitors of the hepatitis C virus (HCV) NS3 protease: probing the role of P2 aryloxyprolines with hybrid structures.

Mrl Rome

Design and synthesis of potent, non-peptide inhibitors of HCV NS3 protease.

Bristol-Myers Squibb

Design and synthesis of bicyclic pyrimidinone-based HCV NS3 protease inhibitors.

Bristol-Myers Squibb Pharmaceutical Research Institute

Phenethyl amides as novel noncovalent inhibitors of hepatitis C virus NS3/4A protease: discovery, initial SAR, and molecular modeling.

Mrl Rome

P1 Phenethyl peptide boronic acid inhibitors of HCV NS3 protease.

Bristol-Myers Squibb Pharmaceutical Research Institute

Azapeptides as inhibitors of the hepatitis C virus NS3 serine protease.

Schering-Plough Research Institute

Solution and solid-phase synthesis of potent inhibitors of hepatitis C virus NS3 proteinase.

Roche Discovery Welwyn

Structure-activity relationship studies of a bisbenzimidazole-based, Zn(2+)-dependent inhibitor of HCV NS3 serine protease.

Bristol-Myers Squibb Pharmaceutical Research Institute

Arylalkylidene rhodanine with bulky and hydrophobic functional group as selective HCV NS3 protease inhibitor.

Institute of Molecular and Cell Biology

Alpha-ketoamides, alpha-ketoesters and alpha-diketones as HCV NS3 protease inhibitors.

Dupont Pharmaceuticals

Potent noncovalent thrombin inhibitors that utilize the unique amino acid D-dicyclohexylalanine in the P3 position. Implications on oral bioavailability and antithrombotic efficacy.

Merck Research Laboratories

Pan-NS3 protease inhibitors of hepatitis C virus based on an R

Uppsala University

The discovery and optimization of naphthalene-linked P2-P4 Macrocycles as inhibitors of HCV NS3 protease.

Bristol-Myers Squibb